Effects of oral contraceptives on diurnal profiles of insulin, insulin-like growth factor binding protein-1, growth hormone and cortisol in endurance athletes with menstrual disturbance
Identifieur interne : 000E14 ( Main/Exploration ); précédent : 000E13; suivant : 000E15Effects of oral contraceptives on diurnal profiles of insulin, insulin-like growth factor binding protein-1, growth hormone and cortisol in endurance athletes with menstrual disturbance
Auteurs : A. Rickenlund [Suède] ; M. Thorn [Suède] ; .. Nybacka [Danemark] ; J. Frystyk [Danemark] ; A. Lindn Hirschberg [Suède]Source :
- Human Reproduction [ 0268-1161 ] ; 2010-01.
Abstract
BACKGROUND Menstrual disturbances in female athletes are often explained as a consequence of energy deficiency. Oral contraceptive (OC) treatment may have favorable metabolic effects. We evaluated effects of OCs on diurnal secretions of insulin, insulin-like growth factor binding protein 1 (IGFBP-1), growth hormone (GH) and cortisol in relation to changes in body composition in athletes with menstrual disturbance compared with regularly menstruating athletes and controls. METHODS Age- and BMI-matched groups of endurance athletes with menstrual disturbance (OAM, n 9) and regularly cycling athletes (RM, n 8) and sedentary controls (CTRL, n 8) were examined, and hormone levels measured, before and after 8 months of treatment with a low-dose combined OC (30 g ethinyl estradiol 150 g levonorgestrel). RESULTS Before OC treatment, the diurnal profile of insulin was lower (P < 0.01) and levels of IGFBP-1 (P < 0.05) and cortisol (P < 0.05) were higher in OAM athletes than in CTRL, whereas GH secretion was higher than in RM athletes (P < 0.05). After treatment, diurnal secretions of these hormones were similar between groups with an increase of IGFBP-1 in the regularly menstruating subjects only (P < 0.001). OC treatment increased body fat mass in OAM athletes (P < 0.01 versus baseline). The change in total fat mass correlated positively with pretreatment diurnal levels of GH (rs 0.67, P < 0.01) and cortisol (rs 0.64, P < 0.01). CONCLUSIONS OC treatment in endurance athletes with menstrual disturbance increases body fat mass and results in diurnal levels of insulin, IGFBP-1, GH and cortisol that are comparable to those in regularly menstruating subjects. These results suggest that OCs improve metabolic balance in OAM athletes.
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DOI: 10.1093/humrep/dep350
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Oral contraceptive (OC) treatment may have favorable metabolic effects. We evaluated effects of OCs on diurnal secretions of insulin, insulin-like growth factor binding protein 1 (IGFBP-1), growth hormone (GH) and cortisol in relation to changes in body composition in athletes with menstrual disturbance compared with regularly menstruating athletes and controls. METHODS Age- and BMI-matched groups of endurance athletes with menstrual disturbance (OAM, n 9) and regularly cycling athletes (RM, n 8) and sedentary controls (CTRL, n 8) were examined, and hormone levels measured, before and after 8 months of treatment with a low-dose combined OC (30 g ethinyl estradiol 150 g levonorgestrel). RESULTS Before OC treatment, the diurnal profile of insulin was lower (P < 0.01) and levels of IGFBP-1 (P < 0.05) and cortisol (P < 0.05) were higher in OAM athletes than in CTRL, whereas GH secretion was higher than in RM athletes (P < 0.05). After treatment, diurnal secretions of these hormones were similar between groups with an increase of IGFBP-1 in the regularly menstruating subjects only (P < 0.001). OC treatment increased body fat mass in OAM athletes (P < 0.01 versus baseline). The change in total fat mass correlated positively with pretreatment diurnal levels of GH (rs 0.67, P < 0.01) and cortisol (rs 0.64, P < 0.01). CONCLUSIONS OC treatment in endurance athletes with menstrual disturbance increases body fat mass and results in diurnal levels of insulin, IGFBP-1, GH and cortisol that are comparable to those in regularly menstruating subjects. These results suggest that OCs improve metabolic balance in OAM athletes.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Rickenlund, A" sort="Rickenlund, A" uniqKey="Rickenlund A" first="A." last="Rickenlund">A. Rickenlund</name></noRegion><name sortKey="Hirschberg, A Lindn" sort="Hirschberg, A Lindn" uniqKey="Hirschberg A" first="A. Lindn" last="Hirschberg">A. Lindn Hirschberg</name><name sortKey="Hirschberg, A Lindn" sort="Hirschberg, A Lindn" uniqKey="Hirschberg A" first="A. Lindn" last="Hirschberg">A. Lindn Hirschberg</name><name sortKey="Thorn, M" sort="Thorn, M" uniqKey="Thorn M" first="M." last="Thorn">M. Thorn</name></country><country name="Danemark"><noRegion><name sortKey="Nybacka, " sort="Nybacka, " uniqKey="Nybacka " first="." last="Nybacka">.. Nybacka</name></noRegion><name sortKey="Frystyk, J" sort="Frystyk, J" uniqKey="Frystyk J" first="J." last="Frystyk">J. Frystyk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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